ANKOR ONE is the nutritional supplement which introduces an innovative concept in animal nutrition, that of “growth-biotic.”
This term refers to products derived from fermentation that introduced into the feed ration are able to maximize the use of nutrients while maintaining high intestinal microbial balance. In growth- biotic blend the action of:
probiotic, understood as a stimulator of immune defenses,
prebiotic, intended as feed that can positively modify the intestinal microbial balance,
growth promoter, understood as an accelerator of intestinal absorption of nutrients
ANKOR ONE is the result of a long research on probiotics and the growth promoters derived from fermentation process. In fact, it was born from the careful work of selection of strains of Saccharomyces and Kluyveromyces capable to producing enzymes endo and exo cellulars, and selection of specific intestinal bacteria species, which are capable of appropriately treated positively stimulate the immune system and the development of fermentative processes in the liquid state and the solid state, able to maximize the production of specific enzymes capable of accelerating the processes hydrolysis and absorption of feeds.
MECHANISM OF ACTION
ANKOR ONE is an innovative product that combines the typical action of metabolic stimulus, long been known, carried on by cultures of Saccharomyces cerevisiae on the intestinal flora, the catalytic properties esplicate the digestibility of dietary principles from the cultures of Kluyveromyces fragilis and Saccharomyces cerevisiae, fermented “solid state “on appropriate substrates with the addition of extracts of Aspergillus oryzae, Bacillus subtilis and lactobacilli.
By virtue of its formulation (cell content of yeasts, with catalytic resulting from their fermentation, etc.) improves the digestibility of the ration, reduces the loss of even highly fermentable substances into the colon, maintains balanced development of the gut microbial populations , especially those of the stretch cecum – colon, decreases the production of toxic catabolites arising from incorrect intestinal fermentation, which are the cause of fatigue liver, increased somatic cell count and loss of production.
Furthermore, ANKOR ONE contains intestinal lactobacilli species specific, with all their metabolites produced during fermentation (organic acids, Biocine, peptides with biological action) that is appropriately treated so as to make them non-viable while remaining extremely active in increasing the level of immune response of the animal. Indeed, the presence of non-denatured proteins of the cell wall of lactobacilli, is able to stimulate the cells of the intestinal epithelium mucipare to the increased production of mucus and simultaneously to increase the production of non-specific immunoglobulin A (IgA). The formation of a thick cover of epithelial cells consists of mucus and immunoglobulin, decreases the possibility that pathogenic microorganisms can adhere to specific sites of attack (lectins) and reduces the passage of toxic substances into the blood system, decreasing the processes inflammation in the liver and the states of toxicosis (liver healthier and lower presence of somatic cells).
Fig. Effects of probiotic bacteria and yeast on intestinal epithelial barrier function. Probiotics affect the epithelial barrier in numerous, diverse ways. This multifactorial approach to enhancing intestinal barrier function aids in developing and maintaining homeostasis. Depending on the strain of bacteria or yeast and the model used, probiotics target the epithelial barrier in the following 3 areas. A: direct effects on the epithelium. Probiotics can increase mucin expression and secretion by goblet cells, thereby limiting bacterial movement across the mucous layer. Augmentation of β-defension expression and secretion into the mucus by epithelial cells can prevent the proliferation of commensals and pathogens, thus also contributing to barrier integrity. Finally, probiotics can enhance tight junction stability, which decreases epithelial permeability to pathogens and their products. B: effects on mucosal immunity. Probiotics can increase levels of IgA-producing cells in the lamina propria and promote secretory IgA (sIgA) secretion into the luminal mucous layer. These antibodies limit epithelial colonization by binding bacteria and their antigens, thus contributing to gut homeostasis. C: effects on other surrounding or infecting bacteria. Probiotics can alter the microbiota composition and/or gene expression, leading to indirect enhancement of the barrier through the commensal bacteria. Furthermore, some probiotics can directly kill or inhibit growth of pathogenic bacteria via expression of antimicrobial factors such as bacteriocins. Probiotics can also compete with pathogens or commensals for binding sites on mucins or epithelial cells, thereby preventing detrimental colonization and contributing to barrier function.
ROLE OF DFM:
The proposed mechanisms for improvement in dairy cattle performance when feeding DFM are outlined below.
Produce of anti-bacterial compounds (acids, bacteriocins, or antibiotics)
Compete against undesirable (pathogenic) organisms for nutrients and/or colonization of the digestive tract (competitive exclusion)
Produce nutrients or other growth factors
Stimulate production of enzymes and/or stimulate growth of natural bacteria
Metabolize or detoxify undesirable compounds (such lactic acid, mycotoxins, etc.)
Stimulate the immune system
Ankor One as a growbiotic is really effective thanks:
The integral colture of Kluyveromyces and Saccharomyces:
Limit the still fermentable protein from the rumen, thanks to the bring of substances catalyzing the protein hydrolysis.
Stimulate the micro-organisms multiplication able to utilize the right-turning lactic acid (Megasphera and Selenomonas);
Notablely reduce the ambiental conditions that promote unexpected change in the intestinal microbic population composition
The presence of intestinal specie specific bacteria fraction, even if rendered inactive and non vital with exclusive productive process:
Stimulate an active and stable autochthonous flora productions;
Increase, on epithelial layer, mucus and antibody. This is mediated from the presence on cellular wall of specific antigens and other biologically active proteic fractions.
Increase the capacity of toxigen compound metabolization from intestinal micro organisms.
Reduce the saprophyte toxigen flora growing. This is due to the biocine presence (specific against numerous pathogen, like Escherichia coli and Clostridium) produced during the fermentation;
Reduce the mucosa inflammatory states due to the presence of acid lactic high quantity.
Increase the ruminal flora stability;
Stimulate the cellulosic bacteria presence;
Improve the intestinal absorption of the diet proteic fraction;
Reduce fiber metabolization times and increase dry matter intake;
Keep steady and positive the flora for all the intestinal tract, the colon inclusive;
Stimulate animal appetite;
Reduce the substances production with histamine-like action along the intestine (less intestinal phlogosis and less somatic cells)
Reduce the toxic compound production (less hepatic abscesses);
Improve the diet global digestibility. This with the bringing in enzymatic action substances;
Increase the heat stress, lowering the basal animal temperature;
Improve the virus and pathogen bacteria resistance;
Improve the fertility.
UTILISATION AND DOSES
Mixed Ankor One in the normal feeds as to provides the follow dosage:
Calves- Sheep and Goats (until 5 -6 months age) 10 g / animal per day
Beef Cows 20 g / animal per day
Dairy cow 30 g / animal per day